Abstract

Abstract Tobaccos smoking products have aheavy impact on the public health of developed countries as well as non- developed by being a main etiologic factor for induction of cardiovascular disease and tobacco-related cancer . The purpose of this study was to determine the influence of tobacco smoking on the measurement of the humoral immune response in 30 pregnant woman with (Type 1) diabetic group in contrast with 30 non smoking pregnant women group and 30 normal women . All studies group have (matched) age and working life.Measurement suggested that diabetic smoker had decrease level of IgG and IgM in their sera it was found that normal individual had mean IgA,IgG, IgM level 1.77mg/ml,8.3 mg/ml and 0.63 mg/ml respectively while non-smoker women suffering from type 1 diabetes had mean level of 2.44 mg/ml,9.94 mg/ml and 1.02 mg/ml .However, the mean level of IgA,IgG and IgM in diabetic smoker sera was determined to be 2.3 mg/ml,7.04 and 0,28mg/ml,respectively. T The obtained result suggest that toxic smoke component were immunosuppressant and may well play apart in the complex immuno-pathogenesis intraction.The increased risk of smoking in insulin dependent diabetic pregnant women during pregnancy is a further reasons to encourage pregnant women to exclude tobacco smoking.