Abstract

In this paper a synthesis of some new 2,4-dihydroxyquinoline and 4-hydroxycoumarin derivatives have been described. The route of preparation involved the uses of Meldrum’s acid as starting material and treated with different substitution hydroxy and amino aromatic compounds and the product have been cyclized by using polyphosphoric acid . The spectral were used (FT-I.R, 1H-NMR ) and CHN analysis to support the structures of the products. The prepared compounds have been tested against Staphylococcus arueus bacteria.