Abstract

The effect of 5µg/ml/day of estradiol 17-β on melanocortin-5-recepter (MC5R); total lipid compounds, essential pheromonal compounds and the histological structure of the preputial glands of intact male mice for 42 days of treatment was investigated. The treatment is resulted in a significant increase of MC5R level as compared with the control group (P<0.01), whereas total lipid contents was altered from that of the control and most of the essential pheromonal compounds were disappeared. The histological structure of the gland is atrophied with a concomitant increase of necrosis regions in the paranchymatous stroma.