Abstract

A number of aminoacetylenic isoindoline-1,3-dione (phthalimide) were prepared through the reaction of phthalimide with potassium hydroxide then alkylation process were carried out for this salt in order to afford N-propargylphthalimide(A1) .The Mannich reaction (three component one pot reaction) was carried out by using the N-propynylphthalimide (A1), with different aldehydes in presence of morpholine or piperidine, as a secondary amines, to yield the desired compounds(A2-A6).The FT-IR, 1HNMR and elemental analysis were consistent with the assigned structures, these compounds also have been tested biologically against bacteria Proteus vulgaris.