Abstract

: Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder and the leading cause of infertility in the women of reproductive age, presenting a wide range of clinical manifestations. Deficiency of 25- OH vitamin D may have a role in PCOS etiopathogenesis and its endocrine and metabolic disregulations. PCOS is underpinned by insulin resistance (IR). Therefore, the aim of presented study was to explore serum 25- OH vitamin D status and its correlation with insulin resistance (IR) in women with PCOS. A case-control study, comprised of 60 newly diagnosed PCOS women with using the Rotterdam criteria and 60 healthy control women were matched with patients age and body mass index (BMI). Patients with past use of hormone therapy and insulin sensitizers or patients with chronic diseases were excluded. Fasting blood samples were analyzed for vitamin D, endocrine and metabolic biomarkers. The results were analyzed using appropriate statistical methods. The result showed that 25-(OH) vitamin D levels were highly significant lower (P< 0.001) in women with PCOS group than in the control group (16.76±4.52 vs 21.89±4.10 ng/ml, respectively). Furthermore, the result showed that 25-(OH) vitamin D levels were negatively correlated (P< 0.001) with fasting insulin (r= - 0.513) and HOMA-IR (r = - 0.465) and positively correlated (P < 0.001) with HDL Cholesterol (r = 0.336). The presented study demonstrated that 25-(OH) vitamin D was highly significant lower in women with PCOS than in the control and an inverse significant association between vitamin D levels and fasting insulin and HOMA-IR in PCOS.