Abstract

ABSTRACT The protective effect of turmeric (Curcuma longa) extract against oxidative stress induced by lithium carbonate (Li2CO3). The project was carried out on thirty male rats divided into five groups each group has six rats. The first group saved as normal control was administrated normal saline only, the second and third groups were received merely at dose 5, 10 mg/kg for induction of oxidative state on rats, While the fourth group was received lithium carbonate at dose 5 mg/kg with turmeric extract at dose 0.5 g for 500 g of dietand the fifth group wasreceived lithium carbonate at dose 10 mg/kg with turmeric extract at dose 0.5 g for 500 g of diet. The results appeared after administration of the phenolic extract of turmeric in rats has oxidative stress via Li2CO3elevated the testes weight, epididymis weight, with raised sperm motility, sperm count, sperm viability, testosterone level, luteinizing hormone level, follicle stimulating hormone level, at the same time, the results demonstrated decreased the sperm abnormality. Conclusively: treatment by turmericextract was produce enhancing role toward oxidative stress induced via Li2CO3 in the rats. Keywords: Oxidative stress, Curcuma longa, Li2CO3, Male fertility, Rat.