Abstract

ABSTRACT : Hepatitis C virus (HCV) infection is a significant is frequency problem found among patients of hemodialysis (HD). The current study aimed at detecting the prevalence of HCV infection among haemodialysis patients that suffering from chronic kidney disease besides assessment the role of virusin increasing the concentration of some important parameters that indicate renal failure including creatinine, urea, albumin,and total serum protein and glucose level in the blood of patient.This study was carried out during the period from May to September (2017), a total of (45) patient on HD was collectedfromSpecialized Center for Diseases and Kidney Transplant in AL-Sadder Medical City in AlNajaf Governorate. 26 male and 19 female with age ranging from 22 – 61 years. Viral detection revealed that there were 19(42%)were positive for HCV on Rapid Immunochromatographic Test (ICT). While the result fromenzyme linked immunosorbent assay (ELISA) technique showed that24(58%) werepositive for anti-HCV antibody but the age group (48- 60) year revealed high significant (p<0.05) in the serum concentration than other age groups. The results of this study showed increase in the level of creatinin in all patients with renal failure, especially those with HCV infection in age group (35-47) year and the results of serum urea level revealed a highly significant (P<0.05) elevation in the serum of all patients had serum urea level above 150mg/dl and especially in age group (22-34 and 35-47) years among patients were positive anti-HCV antibodies. The results were explained to the rest of the parameters increase in albumin and total serum protein levels in all groups of patient’s seropositive anti-HCV antibodies in comparison to negative antiHCV antibodies patient’s. As for the level of glucose were a significant reduction (p<0.05) in the means of glucose level in all age groups of patients seropositive anti-HCV antibodies compared with negative anti-HCV antibodies haemodialysis patients. Key words : Hepatitis virus, chronic kidney disease, hemodialysis patients, ELISA, rapid (ICT).