Abstract

This research involves synthesis of some chalcones derivatives from Acetophenone as starting material. Methods: The derivatives of chalcone compounds [Ch1-Ch4] has been prepared by reaction benzaldehyde derivatives like [4-chlorobenzaldehyde, 4-bromobenzaldehyde, 2-hydroxy1-naphthaldehyde. 3-hydroxybenzaldehyde] with acetophenone.the compound [Ch1,Ch2 and Ch4] enter reaction with urea ,thiouria and guanidine to product pyrimidine derivatives. These compounds [Ch1-Ch4] has been characterized by melting points, [FT.IR] spectroscopy, H1NMR spectroscopy and thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent [benzene: methanol, 4:1]. Antibacterial activity test of three derivative compounds (Ch1a, Ch2b and Ch4c) were done against two multi-drug resistance pathogenic bacteria isolated from patients infected with burn infection. Results: The results proved that Ch4c compound with concentration 200 mg/ml provided best antibacterial activity with inhibition zone diameter 22.62 ± 0.1551 mm and 24 mm against staphylococcus aureus and pseudomonas aeruginosa, respectively.