Abstract

Cyclization reaction has been used to preparation of series heterocyclic azo- azomethine ligands through many steps , the first step: esterification of carboxylic terminal , then cyclization of ester with thiosemicarbazide , followed by second step which involved azotation of amino group of thiadiazole , the third step was reacted with di carbonyl compound ,the last step involved cyclization with compounds containing di nucleophile groups to yield series azo heterocyclic – azomethine ligands. The resulting ligands were investigated bymany techniques like (1H NMR , FT.IR and UV-Visible spectra) with biological test.