Abstract

This work involved prepared of some new series of chemical compounds of 1,3-oxazepine and 1,3-Diazepine derivatives in scheme [I]. First step reaction of sulfadiazine with 4-amino acetophenone product of Schiff base (A)4-((1-(4-aminophenyl)ethylidene)amino)-N-(pyrimidin-2-yl)benzene sulfonamide. Then, Schiff base [A] enter reactions one of with glycine to product five-membrane ring (B) 4-(2-(4-aminophenyl)-2-methyl-5-oxoimidazolidin-1-yl)-N-(pyrimidin-2-yl)benzenesulfonamide. compounds (B) were condensed with different aromatic aldehydes such as (p-hydroxybenzeldehyde, 4-methoxybenzeldehyde and salicyaldehyde] in ethanol absolute absolute to Produce new benzanils derivatives [B1-B3] respectively, Then the Produce of benzanils derivatives [B1-B3] were enter reaction with phathalic anhydride in toluene to Produce new N-(pyrimidin-2-yl)benzenesulfonamide derivatives [B1a-B3a] ,reaction compound [B2a] with Naphthyl amine to give 2-hydroxyphenyl)-4-(naphthalen-2-yl)-1,5-dioxo-3,4,5,5a-tetrahydro-1H-benzo[e][1,3]diazepin-2(9aH)-yl)phenyl)-2-methyl-5-oxoimidazolidin1-yl)-N-(pyrimidin-2-yl) benzenesulfonamide [C].All compounds were characterized by FT-IR spectroscopy and M.P, some of them were characterized by 1H-NMR and spectroscopy analysis. Keyword :- Sulfadiazine, 4-aminoacetophenone, oxaimidizolidine, 1,3-Oxazepine , 1,3-Diazepine