Abstract

Linear growth occurs in 3 stages, During fetal and early infant life, growth is largely regulated by nutrition, during childhood by growth hormone (GH) and during puberty by GH and sex steroids. Short stature may be the result of a condition causing growth failure with a growth rate below the appropriate growth velocity for age and lower of thyroid hormones. The present study showed there was role of thyroid hormones and growth hormone in short stature problems that underlying cause and increased risk for reduced body mass index. Forty children divided into 2 groups were studied. Group I (short stature) consisted of 20 patients (aged 5 years). Group II (control) include 20 children aged 5 years. Hormonal estimation was done including GH,T3, T4, TSH, also study BMI in both groups. Hormonal profile: There was a significant decrease in serum levels of GH, T3 and TSH (P<0.0001) and insignificant change in the T4 between short stature and control( P= 0.05). also in this study showed positive correlation(r=0.561, P<0.01) between Growth and T3 hormones and their effect on short stature.