Abstract

b-thalassemia major (b-TM) is an acute hereditary blood disorder that causes many disorders such as bone dysfunction. Sixty five b-TM patients with b-thalassemia main exposure to blood transfusion with hypodermis iron chelation treatment and 25 healthful persons of the selfsame age were recorded in our research. Serum Parathyroid hormone (PTH), vitamin D3 (Vit. D), calcium, alkaline phosphatase (ALP) and inorganic phosphorus (Pi) and magnesium levels were determined in all persons . In b-TM patients serum PTH, ALP, Pi and magnesium significantly increased while serum Vit. D and calcium levels were decreased as compared with healthful persons. It is determined that bone health is highly compromised in b-TM patients main and bone linked biochemical abnormalities i.e. hypocalcaemia, hypoVitD3 and hyperphosphatemia and hyperparathyroidism are prevalent in b-TM patients. Key words : b-thalassemia, calcium, parathyroid hormone, magnesium and Vit D3.