EVALUATION OF ANTIMICROBIAL ACTIVITY OF PRYMIDINE DERVATIVE OF SOME BACTERIA PATHOGENS FROM URINARY TRACT

Abstract

The current the study is  carried out   investigate  of  antimicrobial activity of uracil isophenol compound against  some bacteria pathogens causing  UTI infection  .  The  urine sample were collecting to hospitals in Najaf of (AL Sadr Medical City  ) for the period from (2 in July 2013 to 2 in September  2013 up) The results were as follows: The proportion of isolated bacteria is  E.coli 40% higher and the proportion of bacteria isolated is Staphylococcus aureus 32% and isolation of bacteria Pseudomonas.aeruginosa  28% in addition to some of the genera were  diagnosed.  .

            In the course of the program directed towards the synthesis of fused nitrogen heterocyclic compound and as an extension of efforts directed towards the development of convenient synthetic approaches for the synthesis one of pyrimidine derivatives called uracil isophenol with an expected broad spectrum of biological activity. Studies have shown that uracil isophenol exhibit various biological activities.     In biological study was to demonstrate  in trial the new compound "uracil isophenol" in different concentration observed the following  E.coli  exhibit sensitivity to all concentration with differ inhibition zone size ; but the same zone size for (10,15,20) mg/ml the inhibition area was reached for 21 mm . in spite of difference in concentration. While   Staphylococcus aureus  also sensitive and the zone larger than E.coli ,and have the same zone  size of  E.coli of concentration(3)mg/ml was  reached for 15 mm . While Pseudomonas.aeruginosa  also exhibit  sensitivity but less than others except for (25) mg/ml it have inhibition zone was reached for size of  25 mm .        Results were compared with control groups were analyzed statistically by results analysis system completely random ANOVA and LSD.